2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121899
    1-Oxo Ibuprofen
    1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    1-Oxo Ibuprofen
  • HY-129099AR
    N-Desmethyltamoxifen hydrochloride (Standard)
    N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
    N-Desmethyltamoxifen hydrochloride (Standard)
  • HY-123144
    N-Hydroxymethylsorafenib
    N-Hydroxymethylsorafenib is a Sorafenib (HY-10201) metabolite, and can be used for research of metabolite of Sorafenib.
    N-Hydroxymethylsorafenib
  • HY-N0873A
    Iso-Sagittatoside A
    Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma.
    Iso-Sagittatoside A
  • HY-143975S
    Loxapine impurity 2-d8
    Loxapine impurity 2-d8 is the deuterium labeled Loxapine impurity 2.
    Loxapine impurity 2-d<sub>8</sub>
  • HY-N15717A
    (threo) 1',2'-Dihydroxyasarone
    (threo) 1',2'-Dihydroxyasarone is an antioxidant found in the roots of Acorus tatarinowii. (threo) 1',2'-Dihydroxyasarone is promising for research of neurological diseases such as dementia.
    (threo) 1',2'-Dihydroxyasarone
  • HY-175079
    (±)17(18)-DiHETE
    (±)17(18)-DiHETE is an oxidized lipid and a metabolite of Eicosapentaenoic Acid (HY-B0660), an orally active omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA).
    (±)17(18)-DiHETE
  • HY-143964S
    Irbesartan impurity 14-d4
    Irbesartan impurity 14-d4 is the deuterium labeled Irbesartan impurity 14. Irbesartan impurity 14-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Irbesartan impurity 14-d<sub>4</sub>
  • HY-136346S
    Ortho-hydroxy atorvastatin lactone-d5
    Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    Ortho-hydroxy atorvastatin lactone-d<sub>5</sub>
  • HY-136239R
    Beclomethasone 17-propionate (Standard)
    Beclomethasone 17-propionate (Standard) is the analytical standard of Beclomethasone 17-propionate. This product is intended for research and analytical applications. Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3].
    Beclomethasone 17-propionate (Standard)
  • HY-N11886
    5-NH2-Baicalein
    5-NH2-Baicalein is an aminated metabolite of Baicalein (HY-N0196). 5-NH2-Baicalein can be used for research of ammonia and ammonia-associated chronic diseases.
    5-NH2-Baicalein
  • HY-15899
    Des(benzylpyridyl) Atazanavir
    Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective HIV-1 protease inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects.
    Des(benzylpyridyl) Atazanavir
  • HY-W509797
    5-(3',4'-Dihydroxyphenyl)-γ-valerolactone
    5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is a gut microbiota metabolite of (-)-Epicatechin (HY-N0001). 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone exhibits antioxidant activity.
    5-(3',4'-Dihydroxyphenyl)-γ-valerolactone
  • HY-118167R
    Monoethylglycinexylidide (Standard)
    Monoethylglycinexylidide (Standard) is the analytical standard of Monoethylglycinexylidide. This product is intended for research and analytical applications. Monoethylglycinexylidide is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver.
    Monoethylglycinexylidide (Standard)
  • HY-18719BR
    Endoxifen hydrochloride (Standard)
    Endoxifen (hydrochloride) (Standard) is the analytical standard of Endoxifen (hydrochloride). This product is intended for research and analytical applications. Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2].
    Endoxifen hydrochloride (Standard)
  • HY-W019773S
    Albendazole sulfone-d7
    Albendazole sulfone-d7 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfone-d<sub>7</sub>
  • HY-G0021S
    N-Desmethylclozapine-d8
    N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.
    N-Desmethylclozapine-d<sub>8</sub>
  • HY-175418
    LaKe
    LaKe is an orally active simple ester prodrug. LaKe is promising for research of metabolic syndrome and neurodegenerative diseases.
    LaKe
  • HY-135588
    Raloxifene 6,4'-Bis-β-D-glucuronide
    Raloxifene 6,4'-Bis-β-D-glucuronide (compound IV) is a metabolite of Raloxifene. Raloxifene is a selective estrogen receptor antagonist for the prevention of osteoporosis.
    Raloxifene 6,4'-Bis-β-D-glucuronide
  • HY-131266
    Febuxostat n-butyl isomer
    		≥98.0%
    Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat n-butyl isomer
Cat. No. Product Name / Synonyms Application Reactivity